On Cue: Striatal Ups and Downs in Addictions

Attending to striatal ups and downs in addictions.

Striatal ups and downs: their roles in vulnerability to addictions in humans.

Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe ...

TRANSSENTENTIAL MEDITATIONS Ups and downs in dynamic semantics TRANSSENTENTIAL MEDITATIONS Ups and downs in dynamic semantics

Mdm2: the ups and downs.

Mdm2 was first described 12 years ago. Interest in this oncogene has risen since its identification as a protein that binds and efficiently inactivates the p53 tumor suppressor protein. This interest was further boosted by the discovery that the mdm2 gene is actually a target for direct transcriptional activation by p53, thus defining an autoregulatory feedback loop for the intracellular modula...

UPs and DOWNs in Cortical Computation